Supplements Moderate evidence

Glucosamine

The old joint supplement that still shows up in reviews.

Glucosamine sulfate has decades of osteoarthritis data and an equally long argument about effect size. Some knees notice it; many do not. It is slower than ibuprofen and less honest in the ads.

How to use

1500 mg glucosamine sulfate daily with food for 8–12 weeks before judging.

Details

Ingredients
Glucosamine sulfate
Benefits
Joint comfort
Dosage
1500 mg daily
When to take
With food
Side effects
Shellfish allergy risk on some sources. GI upset.
Scientific evidence
Meta-analyses are mixed; sulfate form and adequate dose matter more than branding.
Form
Capsule
Third-party tested
Yes

Editorial rating ★ 3.6

Cheap enough to trial for cranky joints. Strength training still does more.

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