Supplements Moderate evidence

Berberine

Plant alkaloid used for glucose disposal support.

Berberine is often compared (too casually) to metformin. It can help post-meal glucose in some people and interacts with many drugs.

How to use

500 mg with the two largest meals, only after checking medications.

Details

Ingredients
Berberine HCl
Benefits
Glucose support, Lipids
Dosage
500 mg 2x daily with meals
When to take
With food
Side effects
Cramping, diarrhea, drug interactions (CYP3A4 and others).
Scientific evidence
Several trials in insulin-resistant adults; medical supervision is wiser than self-experimentation if you take prescriptions.
Form
Capsule
Third-party tested
Yes

Editorial rating ★ 4.1

Real metabolic effects, real interaction risk. Not a candy.

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