Methylfolate is the active folate form used when pregnancy planning, low folate, or MTHFR-aware clinicians enter the chat. It is not a personality gene stack. Excess folate is still excess folate.
Supplements
Strong evidence
Methylfolate
5-MTHF for people who do not love folic acid.
How to use
400–800 mcg 5-MTHF with food unless a clinician set another dose.
Details
- Ingredients
- L-5-methyltetrahydrofolate
- Benefits
- Folate status, Pregnancy planning coverage
- Dosage
- 400–800 mcg typical
- When to take
- Morning, With food
- Side effects
- Irritability or insomnia in a minority at high dose. Can mask B12 deficiency.
- Scientific evidence
- Folate’s neural-tube evidence is among the strongest in nutrition; form debates are secondary to actually getting folate.
- Form
- Capsule
- Third-party tested
- Yes
Editorial rating ★ 4.3
Correct a need. Do not self-prescribe 5 mg because a SNP report was colorful.
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